First Faculty of Medicine, Charles University in Prague Charles University in Prague

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Pharmacology and Toxicology

Pharmacology and toxicology are sciences that study the mechanisms of mutual interactions of substances and medicinal preparations with biologic systems and observe their both favourable and adverse impact on the organism. The final goal is the use of this knowledge in prevention, diagnosis and treatment of human and veterinary conditions.
A great advantage of the study of pharmacology and toxicology is the close interconnection of the theoretic field with all clinical specialties that perform therapy, prevention and diagnosis. The study programme in Pharmacology and Toxicology is therefore suitable not only for those interested in experimental research but also for those seeking their prospective careers in clinical work. The main bias of the study programme, nevertheless, is experimental, at both the pre-clinical and clinical level.
The goal of the doctoral programme Pharmacology and Toxicology is training specialists with deep knowledge in the areas of clinical as well experimental pharmacology and toxicology. This envelops knowledge of wide areas of pharmacokinetics, pharmacodynamics, effects and toxicity of medications, including the knowledge of properties of particular forms of medicinal preparations.

Study obligations
Specific contents of the doctoral studies are provided for each student by an individualized curriculum (“study plan”). Obligatorily, it contains passing at least two subjects provided by any field board within the Co-ordinating Council of doctoral study programmes of biomedicine. It is recommended that at least one of the subjects passed is provided by the field board of Pharmacology and toxicology.

Part of the curriculum is also the language exam in English (examination at the Institute for History of Medicine and Foreign Languages, State Language Examination or an internationally recognized exam, e.g. TOEFL, Cambridge Certificate).

Requirements on creative activities
At least two original publications in journals with IF that pertain to the topic of the thesis and together have a total impact factor not smaller than 1.0. At least in one publication, the doctorand must be the first author.

Requirements on placements taken
A recommended part of study obligations in doctoral studies is taking a study placement abroad. Also welcome is another form of the student’s direct participation in international co-operation, e.g. in an international creative project with results published or presented abroad, etc.

Other study obligations
The individualized curriculum includes continuous publishing activity and presentation of the results at national and international scientific conferences. Also possible / recommendable is the students’ participation in undergraduate tuition (practical classes).

State doctoral examination
The state doctoral examination usually takes place in the 3rd year of doctoral studies. The requisites of admission for the examination are:
- credits from at least 2 subjects passed;
- literature search for the topic (20-30 pages) or an own scientific publication in a reviewed journal (synoptic articles are admitted as well).

The state doctoral examination is held in such an extent that is in keeping with the study programme of the Field Board 10. Its objective is checking the student’s way of scientific thought, i.e. his/her ability of comprehension of the nature of the problem, including the ability of conceiving own ways of solution to the given problems. At the exam, the students are supposed to prove their knowledge of their chosen field to the full extent of the undergraduate level but also the knowledge of trends in research and modern methodology of recent biomedicine as applied to the topic area of his/her dissertation thesis. The examination consists of discussion of the passed subjects completed with credits, discussion of the literature search submitted or the applicant’s own publication, and answering three questions drawn at random. The examining questions for pharmacology and toxicology are displayed at the pages of the Field Board, together with the recommended literature. The examination is oral and its result is expresses in two grades: „prospěl“ (passed), or „neprospěl“ (failed); the chairperson of the board will enter the result in the student’s Study Record Book (“Index”), including the date and his/her signature in the record. The examination can only be repeated once.

Requisites for admission to the defence:
At least two original publications in a journal with an IF pertaining to the topic of the thesis, which together have the total impact factor not lower than 1.0. In at least one of them, the doctorand should be shown as the first author.

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