Introducing Professor Jana Dušková’s Research Team
Professor Jana Dušková’s team works at the Dental Clinic of the First Faculty of Medicine and the General University Hospital in the building of the University Outpatient Clinic in the Charles Square. It includes a Laboratory for Biology of the Mouth and Testing Laboratory for Dental Materials of the General University Hospital. Team’s activities are closely connected to work conducted by research groups of other dental clinics in the Czech Republic, but also by the Department of Occupational Medicine and Institute of Hygiene and Epidemiology (both of the First Faculty of Medicine of the Charles University and General University Hospital), Faculty of Engineering of the Czech Technical University, Institute of Microbiology of the Czech Academy of Sciences, Institute of Endocrinology, and others. The team includes both senior and junior researchers but also students from our faculty.
The core of the team includes Ing. Vlasta Fialová, RNDr. Pavel Bradna, Ing. Radka Vrbová, MUDr. Lucie Himmlová, RNDr. Štěpán Podzimek, Mgr. Taťjana Janatová, MUDr. Adéla Roubíčková, MUDr. Děvana Houšová, and doctoral students MUDr. et MDDr. Martin Bartoš, MDDr. Markéta Janovská, MDDr. Antonín Tichý, and MUDr. Jana Vašáková.
Traditionally, the Laboratory for Biology of the Mouth focuses on research of intolerance of dental materials and diagnosis of oversensitivity to those materials as well as tolerance of orthopaedic or cardiovascular implants using the MELISA test. Based on the results of this test, we can recommend the optimal implant material for a particular patient. Our laboratory now also tests oversensitivity to non-metal materials, especially dental composite materials, adhesive systems, and bone cements used in orthopaedic surgery. We also conduct research into the microbial population of the mouth cavity, especially in connection with treatment of patients with aggressive periodontitis.
The accredited Testing Laboratory for Dental Materials of the General University Hospital is equipped to test physical-mechanic properties of dental materials and adhesive systems in accordance with international ISO norms adopted into Czech and European technical norms. In addition to accredited tests, we also conduct further non-accredited tests and research as part of research projects, grants, or undergraduate or doctoral studies. In collaboration with Professor Daniela Pelclová of the Department of Occupational Medicine, we are conducting a study into the effects of nanoparticles released when finishing dental treatment using composite materials. In collaboration with the Institute of Endocrinology, we also investigate the effects of conditions of polymerisation of photo-composite the materials on the release of bisphenol-A and its analogues, which imitate the effects of oestrogen and function as hormonal disruptors. In collaboration with the Dental Clinic of the Medical Faculty of the Charles University and University Hospital Hradec Králové, we measure the levels of stress hormones during dental examination in child patients who are especially hard to treat. In recent years, we saw a sharp increase in the demand for histological preparations of bone tissue in conjunction with newly developed biomaterials. Especially valuable to our experimental work is the new micro-CT SkyScan 1272, thanks to which we are able to characterise the organisation of spatial structure (2D/3D) of examined samples in a non-destructive way.
Grants and Projects
Researchers of Professor Dušková’s team participate in PROGRESS Q29 project ‘Diseases of the orofacial system: Incidence, mechanisms, prevention, treatment, interactions’. Currently, the team works on two grants of the Czech Health Research Council, namely ‘The use of methods of parallel sequencing in monitoring the dynamics of oral microbiome in the course of development and therapy of periodontitis’ and ‘The use of lymphocytes of hypersensitive patients in preclinical testing of advance titanium-based materials modified by ion beam’.
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